Scientist 2, Cell Biology in Hematology OR Musculoskeletal
Scientist 2, Cell Biology in Hematology OR Musculoskeletal
He/she is a highly motivated cell biologist with experience in Hemotology (non Oncolgy) or Musculoskeletal. We have openings in both therapeutic areas. As a Scientist 2 you are responsible for conceiving strategies, leading the development, evaluation and implementation of state-of-the-art cell-based disease models to identify novel therapeutic interventions, in support of preclinical proof-of-concept and mechanisms of actions investigations of novel therapeutics. These Scientists are expected to be a mentor for a recognized area of technical expertise within the department.
RESPONSIBILITIES:
- Provide scientific and intellectual input to guide project-related cell biology proof-of-concept and investigative efforts within the context of interdisciplinary project teams.
- Plan and execute laboratory research.
- Initiate, direct and execute the development, optimization, qualification of robust cell-based assays
- Analyze data with applicable bioinformatics tools/scientifically sound interpretation and present data at group/departmental meetings.
- Able to troubleshoot experiments based on thorough understanding of assay principles
- Author technical reports and SOPs associated with the cellular and molecular assays developed and qualified.
- Provide support to collaborating functional groups, as needed
- Work with junior research associates and scientists on experimental design, troubleshooting, assay optimization and data interpretation, if applicable.
- Maintains broad knowledge of state-of-the-art principles and theories.
- Participate in exploratory studies driving the evaluation of state-of-the-art new technology platforms, and innovative upgrades for existing assay platforms.
- Identify, develop and maintain relationships with contract research organizations to maximize group productivity and assure inclusion of latest scientific thinking and guidelines in the research plan.
- Contribute to the peer review process, both internally and externally, to help assure BioMarin translational research is conducted at the highest level of quality, integrating business and development objectives.
- Makes major contributions to scientific literature and conferences.
EDUCATION /REQUIREMENT:
- A Ph.D. in Cell Biology, Genetics or a related field with postdoctoral and at least 2+ years of industry experience are required
- Demonstrated experience in tissue culture with iPCS, primary cells (e.g. hepatocytes)
- Proficiency with flow cytometry including designing and optimizing multi-parameter flow cytometry panels
- Proficiency in developing and optimizing high-content imaging bioassays independently with limited guidance a plus
- Experience with confocal microscopy and live-cell imaging.
- Proficiency in various molecular biology analytical methods (qPCR or ddPCR), and other standard molecular biology techniques.
- Background in viral and non-viral gene therapy, cellular or molecular biology is a plus
- Experience with analytical and/or statistical software (e.g., JMP, Softmax Pro, XLfit, Gen5 etc.), is highly beneficial
- Demonstrated ability to work in a fast-paced, team-orientated environment with aggressive timelines
- Passion for continued learning and helping others learn.
- Maintain detailed records of experimental protocols and data in electronic laboratory notebook in accordance with company policy
- Collaborative, team-oriented, consistently looks for win-win solutions to problems. Ability to interact successfully with team members from a wide variety of functional areas and all levels of contribution and expertise.
- Publication record supporting a consistent contribution to the success of research projects
- Strong communication (verbal and written) skills
PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.